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Clenbuterol (Cutting) The steroid Clenbuterol is used for the treatment of breathing disorders such as asthma. Clenbuterol should be avoided by patients with adrenal insufficiency because of its high plasma clearance. Clenbuterol has been reported to be used in the management of pulmonary exacerbations of asthma, but most case series and case reports show a positive relationship between Clenbuterol use and the onset of asthma exacerbations. [PMID 23705066] N-Hydroxyethyl-N-methylbutizine (Dosage Reduction) Dosages of N-hydroxyethyln methylbutizine, ethyl estradiol, and progestin may be reduced with clonidine. In a small study, clonidine was associated with decreased clearance of estrogen and progestins. (Lanfranchi et al. JAMA, 1984;248:937-943.) [PMID 20706093] Progestin (Progestogen) As a long-acting progestogen, estrogen, and progesterone can be reduced by clonidine. [PMID 16677898] Hydrocortisone (Hysterectomy) Estrogens The estrogen receptor agonist Cyproterone Acetate is used to promote the onset of menstruation and for the maintenance of normal sexual function. [PMID 23010869] The estrogen receptor antagonist, aromatase inhibitor, and/or aromatase inhibitor inhibitors include clomiphene citrate, clomiphene sulphate, aldactone, and metoclopramide. Estrogens and progestins are used to treat infertility (including menopause), promote pregnancy, reduce prolapse, relieve pain, and decrease menstrual cramps, but this is not a standard therapy in the management of menopausal disorders such as endometriosis. Chronic use of estrogens and progestins may cause an increased risk of prostate cancer in men, but this is not the case for estrogen. In one retrospective study, 7,000 men developed prostate cancer after lifetime exposure to estrogens, 2,000 during the last year of estradiol replacement therapy, and 3,000 who did not use estrogens. [PMID 16330029] Progestins may cause a transient elevation in HDL cholesterol in some patients, but in men (particularly those taking a large dose of estrogen), HDL cholesterol may be reduced as the dose is raised. An increased risk of Related Article: